Pluryal Densify (Skin‐Nurturing / Hand-Injected)

Unlock your skin’s inherent beauty with the “Skin-Nurturing Injection” that promotes skin regeneration

  • Improved Skin Texture (Enhanced Luster, Firmness, and Grain)
  • Excellent Immediate and Lasting Effects
  • Natural Finish

If you are have these concerns

  • Want to refine skin texture and balance.
  • Want to boost firmness and elasticity.
  • Want to improve redness and uneven skin tone.
  • Concerned about enlarged pores.
  • Concerned about fine lines on the face.
  • Want a more translucent complexion.

What is Pluryal Densify?

Pluryal Densify

Improvable Symptoms

FirmnessDullnessFine LinesPoresDry Skin

Pullreal Densify, a popular skin-enhancing injection, is a formulation primarily composed of polynucleotides. This injectable not only delivers deep hydration to the skin but also strengthens the skin’s inherent resilience by promoting collagen production.

This formulation supports skin repair and regeneration, developed to improve rough skin, redness, and dryness. It combines three key ingredients: PN (polynucleotide), non-crosslinked hyaluronic acid, and antioxidant-rich mannitol. This combination comprehensively improves skin hydration, elasticity, and texture.

PN (polynucleotide) has a structure very similar to DNA. It is a component that is unlikely to cause adverse reactions and acts directly on skin cells and functions. By enhancing the skin’s recovery ability, this ingredient promotes collagen production and increases skin hydration. The result is firmer, more elastic skin, leaving it smooth and healthy.
Non-crosslinked hyaluronic acid provides immediate hydration, allowing you to feel improvement right after injection. It then acts deep within the dermis, gradually repairing and regenerating cells.

Features

  • Wide-ranging effects including wrinkle improvement, pore reduction, brightening, hydration, and firmness enhancement
  • Noticeable improvement in firmness and radiance often felt after just one treatment
  • Can expect overall skin texture improvement
  • Natural finish, volume enhancement without unnatural appearance

Advantages

  • Relatively long-lasting effects
  • Minimal downtime
  • Anti-aging benefits through antioxidant effects

Disadvantages

  • Rarely causes mild stinging or redness (usually subsides within hours)
  • Does not provide volume-enhancing effects like hyaluronic acid injections
  • Results vary, especially for deep wrinkles and sagging skin

Pluryal Densify Treatment
at Our Clinic

Pluryal Densify

Hand-injected with Ultra-fine Needles — Tailored Approach

The “Skin Nurturing Injection” promotes skin regeneration. The director personally administers it with a “hand-injected” hydrating injection style.

Each area of the face is approached with optimal depth and dosage. Treatment is also available for the neck and backs of hands, especially effective where machine-based treatments have had limited results.

Key Ingredients & Their Effects

Polynucleotides (PN)

『A biologically derived substance composed of DNA fragments. When injected just beneath the skin, it enhances self-repair, stimulates regeneration of damaged cells, promotes new blood vessel formation, and helps normalize turnover in skin layers.

Non-crosslinked Hyaluronic Acid

Because the molecules are not crosslinked, they absorb more easily, delivering moisture deep into the skin and providing immediate hydration.

Mannitol

A sugar alcohol with powerful antioxidant effects; it slows hyaluronic acid breakdown (prolonging its effects) and protects the skin from oxidative stress (e.g. UV, environmental damage).

Pluryal Densify

Benefits of Manual Waterlight Injection

Rather than uniform machine-based injections, manual injections allow the physician to carefully determine each injection point, enabling a meticulous treatment tailored to the specific condition of each area.

While machine-based hydrating injections are certainly effective, their square applicator heads can sometimes struggle to precisely target specific areas. This is why manual hydrating injections are popular, with the major benefit being that results are often more readily noticeable.

Side Scroll
Comparison with Machine-Based Methods
Manual HydraFacial Injection Machine-Based HydraFacial Injection
Injection Method Physician manually injects solution directly into each area Specialized injector with multiple ultra-fine needles at the tip
Injection Technique Milli-meter precision adjustments to depth, volume, and placement based on skin condition
Targeted, concentrated injection into specific areas		 Consistent, uniform injection throughout
Limited capacity for fine adjustments
Treatment Time Approx. 30 min (around 1 hour including anesthesia) Approx. 15-30 min

Treatment Process

1

Consultation

Explanation of the procedure, post-treatment care, and assessment of skin condition.

2

Cleansing and Disinfection

Remove makeup and carefully clean the injection site.

3

Treatment

Topical anesthesia (optional)

A numbing cream is applied (approx. 15-20 minutes). For full face or under-eye injections, we recommend adding topical anesthetic (¥3,300).

Injection (Hand-injected Aqua Glow style)
Using a 34G ultrafine needle, small amounts are carefully injected into the shallow layers of skin. Some mild stinging may occur, but pain is kept minimal. The procedure takes about 30 minutes total.

Post-treatment care
After the treatment, redness, bruising, and slight swelling may occur, but these will subside within half a day to a few days.

Treatment Overview

Treatment Time

About 10 minutes (It takes around 30 minutes in total, including anesthesia)

Number of Treatment

Initially, one treatment every 3-4 weeks, for 4 sessions in total

Applicable

For those seeking to boost skin firmness and elasticity, Improve skin texture, or Interested in skin rejuvenation treatments

Not Applicable
  • Pregnant or breastfeeding individuals, or those trying to conceive
  • Individuals undergoing treatment for skin diseases or with pre-existing conditions (immune system disorders, epilepsy, etc.)
  • Individuals with salmon allergy
  • Individuals with poorly controlled diabetes
  • Individuals undergoing treatment for herpes
  • Individuals with a history of skin cancer
  • Individuals with current or past immune dysfunction, or those undergoing immunosuppressive therapy
  • Individuals with a history of hypersensitivity to any component of this product
Precautions
  • Immediately after treatment, you may experience small bumps resembling mosquito bites, which typically disappear within half a day.
  • Some redness or swelling may remain at the injection site, usually subsiding within 1 to 2 days.
  • Significant swelling or bruising may occur, but this typically becomes less noticeable within 1 to 3 weeks.
  • Rarely, allergic symptoms such as weakness, dizziness, blurred vision, nausea, abdominal pain, difficulty breathing, loss of consciousness, or convulsions may occur.

Daily Life Post-treatment
  • Makeup (preferably starting the next day if possible) and all facial cleansing are permitted immediately after the procedure.
  • On the day of the procedure, please take a shower. Baths are permitted starting the next day.

Frequently Asked Questions

You may feel a slight prick during the injection. However, we use ultra-fine needles and our experienced physicians perform the procedure quickly, minimizing any discomfort.

There is minimal downtime. If redness or swelling occurs after the procedure, it typically improves within 1 to 2 days.

Results vary by individual, but many patients begin to notice effects after 3 to 4 sessions. Continued treatment can lead to greater effectiveness.

Price（include tax）

Pluryal DensifyPlupyal Densify Hand-Injected
1 vial (2.0cc)
1 time¥77,000
4 sessions¥280,500
2 Vials (4.0cc)
1 time¥148,500
4 sessions¥561,000
Surface Anesthesia
1 time¥3,300