{"id":2257,"date":"2026-04-30T19:21:16","date_gmt":"2026-04-30T10:21:16","guid":{"rendered":"https:\/\/www.yamate.clinic\/en\/?page_id=2257"},"modified":"2026-05-01T09:41:42","modified_gmt":"2026-05-01T00:41:42","slug":"isotretinoin","status":"publish","type":"page","link":"https:\/\/www.yamate.clinic\/en\/medicine\/isotretinoin\/","title":{"rendered":"Isotretinoin Oral Medication"},"content":{"rendered":"<p><main id='content' role='main'><\/p>\n<section class='hero-area bg-img-center content-space-1'>\n<div class='container-xxl pt-3 pt-lg-5 px-0'>\n<div class='d-flex'>\n<div class='container d-flex justify-content-end flex-column min-vh-50 min-vh-lg-35 content-space-1 content-space-lg-b-3'>\n<div class='row align-items-center'>\n<div class='col-12 col-lg-7'>\n<h1 class='display-5 text-black'>Isotretinoin Oral Medication<\/h1>\n<nav aria-label='breadcrumb'>\n<ol class='breadcrumb'>\n<li class='breadcrumb-item'><a href='https:\/\/yamate.clinic'>Home<\/a><\/li>\n<li class='breadcrumb-item'><a href='https:\/\/yamate.clinic\/en\/medicine'>Medicine<\/a><\/li>\n<li class='breadcrumb-item'>Isotretinoin<\/li>\n<\/ol>\n<\/nav>\n<\/div>\n<div class='col-11 col-lg-5 me-auto'>\n<div class='diag-line-image mt-4 mt-lg-0'>\n<img src='https:\/\/yamate.clinic\/wp-content\/themes\/yycja\/assets\/img\/medicine-img\/isotretinoin-image.jpg' class='img-fluid' alt='Isotretinoin'><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class='service-area content-space-2'>\n<div class='container'>\n<div class='about w-lg-75 wow fadeInUp'>\n<div class='service-heading mb-3'>\n<h2 class='text-primary'>Isotretinoin (Acnetol) Oral Medication<\/h2>\n<\/div>\n<p class='lead'>For persistent acne, difficult inflammatory acne, and sebum-rich skin type, an internal-treatment option is isotretinoin oral medication, Acnetol.<\/p>\n<p class='mb-3'>Acnetol is an oral medication whose active ingredient is isotretinoin (Isotretinoin).<\/p>\n<p class='mb-3'>Isotretinoin is a type of retinoid (vitamin A derivative) and is a highly effective oral treatment for severe acne and recurring inflammatory acne.<\/p>\n<p class='mb-3'>Because it suppresses multiple causes of acne \u2014 clogging of pores, excessive sebum production, the proliferation of acne bacteria, and inflammation \u2014 it is expected to have such reliable efficacy that it is sometimes called a \u201clast resort\u201d for acne treatment. Isotretinoin is commonly prescribed in the United States as a first-line acne medication, but it is an unapproved medication in Japan.<\/p>\n<p class='mb-3'>Acnetol is manufactured by NOD in India, and it is sold in Japan under supervision from Japan, so the package labeling is Japanese.<\/p>\n<\/div>\n<\/div>\n<\/section>\n<section class='service-area content-space-2'>\n<div class='container'>\n<div class='row justify-content-between'>\n<div class='col-9 col-lg-4 mb-5 mb-lg-0'>\n<img src='https:\/\/yamate.clinic\/wp-content\/themes\/yycen\/assets\/img\/medicine-img\/isotretinoin.jpg' class='img-fluid' alt='Isotretinoin'><\/div>\n<div class='col-12 col-lg-7'>\n<h4>Effects and benefits<\/h4>\n<div class='item-box my-5'>\n<p class='mb-0'><span class='item-2'>Inflammatory acne<\/span><span class='item-2'>Comedones<\/span><span class='item-2'>Sebum overproduction<\/span><span class='item-2'>Adult acne<\/span><span class='item-2'>Wide-area acne<\/span><\/p>\n<\/div>\n<div class='w-50 border-bottom border-secondary mb-5'><\/div>\n<div class='mb-5'>\n<h5>1. Powerful suppression of sebum production<\/h5>\n<p class='ps-3'>Acne is caused by a complex interplay of excessive sebum production, clogged pores, proliferation of bacteria, and inflammation. Isotretinoin suppresses the activity of sebaceous glands and approaches the root causes of acne.<\/p>\n<\/div>\n<div class='mb-5'>\n<h5>2. Suitable for recurrent and treatment-resistant acne<\/h5>\n<p class='ps-3'>Even if acne temporarily improves with topical medication or antibiotics, it can come back once the medication is stopped. Isotretinoin is often used to improve chronic acne tendencies.<\/p>\n<\/div>\n<div class='mb-0'>\n<h5>3. Early intervention to reduce acne scars<\/h5>\n<p class='ps-3'>If severe inflammatory acne continues for a long time, it can lead to persistent redness, pigmentation, and pitted scars. Appropriate treatment before inflammation lasts can help reduce future skin damage.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class='service-area content-space-2'>\n<div class='container-xl'>\n<div class='trouble wow fadeInUp bg-light rounded-3 p-4'>\n<div class='row justify-content-between align-items-center'>\n<div class='col-12 col-lg-5 text-lg-center'>\n<div class='section-heading'>\n<h2 class='text-primary'>Recommended for<\/h2>\n<\/div>\n<\/div>\n<div class='col-12 col-lg-6'>\n<ul class='list-unstyled'>\n<li><span class='mdi mdi-check mdi-24px me-3 text-graybeige'><\/span>Acne appears repeatedly in the same spot<\/li>\n<li><span class='mdi mdi-check mdi-24px me-3 text-graybeige'><\/span>Red or pustular acne is difficult to heal<\/li>\n<li><span class='mdi mdi-check mdi-24px me-3 text-graybeige'><\/span>Oily skin that feels constantly sticky<\/li>\n<li><span class='mdi mdi-check mdi-24px me-3 text-graybeige'><\/span>You want to treat acne thoroughly before it becomes a scar<\/li>\n<li><span class='mdi mdi-check mdi-24px me-3 text-graybeige'><\/span>Repeated acne on the back or chest as well as on the face<\/li>\n<li><span class='mdi mdi-check mdi-24px me-3 text-graybeige'><\/span>You want to improve acne from the root<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class='service-area content-space-2'>\n<div class='container'>\n<div class='method w-lg-75 wow fadeInUp'>\n<div class='service-heading mb-3'>\n<h2 class='text-primary'>How to take<\/h2>\n<\/div>\n<ul class='list-unstyled'>\n<li>Usually once a day after meals that ideally contain fat (dose adjusted by weight)<\/li>\n<li>One course is 5 months (maximum 6 months)<\/li>\n<li>If the effect is insufficient after one course, take a 3-month break, and consider a second course<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/section>\n<section class='service-area content-space-2'>\n<div class='container'>\n<div class='service-item-heading mb-7'>\n<h2 class='text-primary'>Case<\/h2>\n<\/div>\n<div class='row mb-5 justify-content-center'>\n<div class='col-12 col-lg-7 mb-5 mb-lg-0'>\n<img class='img-fluid' src='https:\/\/yamate.clinic\/wp-content\/themes\/yycen\/assets\/img\/medicine-img\/isotretinoin-ba-2.jpg' alt='Isotretinoin'><\/div>\n<div class='col-10 col-lg-3'>\n<h6>Course with Acnetol 20mg<\/h6>\n<p>\u30fbMale in his 20s<br class='br'>\u30fb4 months after starting 20mg\/day<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class='service-area content-space-t-1 content-space-b-2'>\n<div class='container'>\n<div class='notice wow fadeInUp'>\n<div class='service-heading wow fadeInUp mb-7'>\n<h2 class='text-primary'>Cautions and contraindications<\/h2>\n<\/div>\n<p class='mb-5'>This treatment uses drugs and\/or medical devices that are not approved in Japan.<br class='br'>The drug used for treatment is individually imported under the judgment and supervision of the clinic physician.<\/p>\n<div class='row'>\n<div class='col-12'>\n<div class='row mb-3 pb-2 border-bottom'>\n<div class='col-12 col-md-2'>\n<h6>Contraindications<\/h6>\n<\/div>\n<div class='col-12 col-md-10'>\n<ul class='ms-n3'>\n<li>Pregnant or breastfeeding, or trying to conceive<\/li>\n<li>Within 6 months of LASIK surgery<\/li>\n<li>Under 18 years old (growth period)<\/li>\n<li>Currently taking tetracycline antibiotics (Minomycin, Vibramycin, Ledamycin, Acromycin V). After stopping, allow a 2-week interval before prescribing.<\/li>\n<li>Taking systemic steroids; allergies to parabens, soy, peanuts; aspirin-induced asthma<\/li>\n<li>Severe hepatic dysfunction, renal dysfunction, hyperlipidemia, hypercholesterolemia, hypervitaminosis A, ulcerative colitis, Crohn&#8217;s disease, depression or depressive tendency<\/li>\n<li>Chronic respiratory disorders (may worsen)<\/li>\n<li>Severe muscle weakness or atrophy (may worsen)<\/li>\n<li>Angle-closure glaucoma or predisposition such as narrow angles (may worsen symptoms)<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class='row mb-3 pb-2 border-bottom'>\n<div class='col-12 col-md-2'>\n<h6>Precautions<\/h6>\n<\/div>\n<div class='col-12 col-md-10'>\n<ul class='ms-n3'>\n<li>Common side effects include dryness of the lips, rough\/dry skin, and dryness of eyes, nose, and throat.<\/li>\n<li>Nosebleeds, thinning of the stratum corneum, peeling, nail changes, hair loss, headache, telangiectasia, muscle pain, and joint pain may occur.<\/li>\n<li>Regular blood tests are needed because liver function and lipid metabolism can be affected.<\/li>\n<li>Teratogenicity: cannot be used during pregnancy, breastfeeding, or while trying to conceive.<\/li>\n<li>No blood donation during treatment and for 6 months after discontinuation.<\/li>\n<li>If blood test results are poor, medication may not be prescribed; because it is a pharmaceutical product, refunding unused medication is not possible.<\/li>\n<li>In about the first month, acne may temporarily worsen as a flare.<\/li>\n<li>Dermatologic procedures are generally avoided during treatment; treatment can resume 1 month after completion.<\/li>\n<li>Cannot be used together with progestin-only oral contraceptives (mini-pill).<\/li>\n<li>Avoid direct sunlight and high humidity; store at room temperature.<\/li>\n<li>Keep out of reach of children to prevent accidental ingestion.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class='service-area content-space-2'>\n<div class='container'>\n<div class='faq wow fadeInUp'>\n<div class='service-heading mb-7'>\n<h2 class='text-primary'>Frequently asked questions<\/h2>\n<\/div>\n<div class='accordion' id='accordionExample'>\n<div class='accordion-item'>\n<div class='accordion-header' id='heading-a1'>\n<a class='accordion-button collapsed' role='button' data-bs-toggle='collapse' data-bs-target='#collapse-a1' aria-expanded='false' aria-controls='collapse-a1'>How soon will I feel the effect?<\/a><\/div>\n<div id='collapse-a1' class='accordion-collapse collapse' aria-labelledby='heading-a1' data-bs-parent='#accordionExample'>\n<div class='accordion-body'>There are individual differences, but improvements generally appear gradually over several weeks to a few months. Early in treatment, acne may temporarily worsen, but we determine whether to continue by observing skin condition.<\/div>\n<\/div>\n<\/div>\n<div class='accordion-item'>\n<div class='accordion-header' id='heading-a2'>\n<a class='accordion-button collapsed' role='button' data-bs-toggle='collapse' data-bs-target='#collapse-a2' aria-expanded='false' aria-controls='collapse-a2'>Will it relapse?<\/a><\/div>\n<div id='collapse-a2' class='accordion-collapse collapse' aria-labelledby='heading-a2' data-bs-parent='#accordionExample'>\n<div class='accordion-body'>Many patients do not relapse after treatment, and it is considered a fundamental treatment, but recurrence can occur.<\/div>\n<\/div>\n<\/div>\n<div class='accordion-item'>\n<div class='accordion-header' id='heading-a3'>\n<a class='accordion-button collapsed' role='button' data-bs-toggle='collapse' data-bs-target='#collapse-a3' aria-expanded='false' aria-controls='collapse-a3'>How is it different from mail-order products?<\/a><\/div>\n<div id='collapse-a3' class='accordion-collapse collapse' aria-labelledby='heading-a3' data-bs-parent='#accordionExample'>\n<div class='accordion-body'>Under a physician&#8217;s management, early detection of adverse effects, correct guidance on how to take the medication, and regular examinations are possible. Safety assurance is the biggest difference.<\/div>\n<\/div>\n<\/div>\n<div class='accordion-item'>\n<div class='accordion-header' id='heading-a4'>\n<a class='accordion-button collapsed' role='button' data-bs-toggle='collapse' data-bs-target='#collapse-a4' aria-expanded='false' aria-controls='collapse-a4'>When are blood tests performed?<\/a><\/div>\n<div id='collapse-a4' class='accordion-collapse collapse' aria-labelledby='heading-a4' data-bs-parent='#accordionExample'>\n<div class='accordion-body'>If there are no contraindications, medication is generally prescribed at the first visit, and blood tests are performed at the same time. You can start taking the medication without waiting for blood test results, but if results are poor, you must stop taking it.<br \/>\nFor a 5-month course with blood tests every 2 months, a total of 3 blood tests are required.<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class='service-area content-space-t-2 content-space-b-3'>\n<div class='container'>\n<div class='price wow fadeInUp'>\n<div class='service-heading mb-7'>\n<h2 class='text-primary'>Price <span class='fs-5'>(include tax)<\/span><\/h2>\n<\/div>\n<div class='row mb-5 justify-content-center'>\n<div class='col-12 col-sm-11'>\n<div class='alert bg-light border mb-3'>\n<div class='row p-0 align-items-center'>\n<div class='col-12 col-md-4'>\n<h6 class='mb-0'>Isotretinoin 10mg (30 tablets)<\/h6>\n<\/div>\n<div class='col-12 col-md-3 text-end'>\n<span class='me-3'>1 time<\/span><span class='amount'>\u00a511,000<\/span><\/div>\n<div class='col-12 col-md-5 text-end'>\n<span class='me-3'>4-month set <span class='fs-5'>(includes 2 blood tests)<\/span><\/span><span class='amount'>\u00a544,000<\/span><\/div>\n<\/div>\n<\/div>\n<div class='alert bg-light border mb-3'>\n<div class='row p-0 align-items-center'>\n<div class='col-12 col-md-4'>\n<h6 class='mb-0'>Isotretinoin 20mg (30 tablets)<\/h6>\n<\/div>\n<div class='col-12 col-md-3 text-end'>\n<span class='me-3'>1 time<\/span><span class='amount'>\u00a514,960<\/span><\/div>\n<div class='col-12 col-md-5 text-end'>\n<span class='me-3'>4-month set <span class='fs-5'>(includes 2 blood tests)<\/span><\/span><span class='amount'>\u00a559,840<\/span><\/div>\n<\/div>\n<\/div>\n<div class='alert bg-light border mb-3'>\n<div class='row p-0 align-items-center'>\n<div class='col-12 col-md-9'>\n<h6 class='mb-0'>Blood test<\/h6>\n<\/div>\n<div class='col-12 col-md-3 text-end'>\n<span class='me-3'>Once a month<\/span><span class='amount'>\u00a53,300<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<p><\/main><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Isotretinoin Oral Medication Home Medicine Isotretinoin Isotretinoin (Acnetol) Oral Medication For persistent  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":476,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/pages\/2257"}],"collection":[{"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/comments?post=2257"}],"version-history":[{"count":5,"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/pages\/2257\/revisions"}],"predecessor-version":[{"id":2267,"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/pages\/2257\/revisions\/2267"}],"up":[{"embeddable":true,"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/pages\/476"}],"wp:attachment":[{"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/media?parent=2257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}