{"id":1908,"date":"2026-03-19T16:47:39","date_gmt":"2026-03-19T07:47:39","guid":{"rendered":"https:\/\/www.yamate.clinic\/en\/?page_id=1908"},"modified":"2026-04-21T17:03:01","modified_gmt":"2026-04-21T08:03:01","slug":"nad-nasal-spray","status":"publish","type":"page","link":"https:\/\/www.yamate.clinic\/en\/external\/nad-nasal-spray\/","title":{"rendered":"NAD+ Nasal Liposome Kit"},"content":{"rendered":"<p><main id=\"content\" role=\"main\"><\/p>\n<section class=\"hero-area bg-img-center content-space-1\">\n<div class=\"container-xl content-space-t-3 content-space-t-lg-4\">\n<div class=\"w-lg-75 text-center mx-lg-auto mb-5 mb-lg-10\">\n<div><span class=\"text-cap\">Future-Oriented Conditioning<\/span><\/div>\n<h1>NAD+ Nasal Liposome Kit<\/h1>\n<p class=\"lead\">A new, needle-free NAD+ routine.<\/p>\n<\/div>\n<p><img decoding=\"async\" class=\"img-fluid\" src=\"https:\/\/yamate.clinic\/wp-content\/themes\/yycen\/assets\/img\/bg-img\/bg-nad-spray.jpg\" alt=\"NAD+\"><\/p>\n<nav aria-label=\"breadcrumb\">\n<ol class=\"breadcrumb\">\n<li class=\"breadcrumb-item\"><a href=\"https:\/\/yamate.clinic\/en\">Home<\/a><\/li>\n<li class=\"breadcrumb-item\"><a href=\"https:\/\/www.yamate.clinic\/en\/external\/\">External<\/a><\/li>\n<li class=\"breadcrumb-item\">Nad Nasal Spray<\/li>\n<\/ol>\n<\/nav>\n<\/div>\n<\/section>\n<section class=\"service-area content-space-1\">\n<div class=\"container\">\n<div class=\"about wow fadeInUp\">\n<div class=\"section-heading mb-7\">\n<h2 class=\"text-primary\">What is NAD+?<\/h2>\n<\/div>\n<div class=\"row justify-content-end justify-content-sm-between\">\n<div class=\"col-12 col-md-6 mb-5 mb-md-0\">\n<p class=\"mb-3\">\n<strong>NAD+ (Nicotinamide Adenine Dinucleotide) <\/strong>is a central coenzyme found in all cells that supports mitochondrial function, which produces energy (ATP).<\/p>\n<p class=\"mb-3\">\nIt is also considered extremely important for maintaining health and preserving youthfulness because it activates the \u201csirtuin genes\u201d (longevity genes) involved in DNA repair and cellular anti-aging. However, NAD+ levels in the body decline with age, and it is said that they drop to about half of their peak levels around the age of 45.<\/p>\n<\/div>\n<div class=\"col-9 col-md-5\">\n<img decoding=\"async\" src=\"https:\/\/yamate.clinic\/wp-content\/themes\/yycen\/assets\/img\/external-img\/nad-image.jpg\" class=\"img-fluid\" lat=\"NAD+\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"service-area content-space-2\">\n<div class=\"container\">\n<div class=\"feature wow fadeInUp mb-7\">\n<div class=\"section-heading mb-7\">\n<h2 class=\"text-primary\">Purpose and Features of This Treatment<\/h2>\n<\/div>\n<div class=\"row justify-content-center justify-content-lg-between\">\n<div class=\"col-12 col-md-6 mb-5 mb-md-0\">\n<p class=\"lead\">This treatment aims to efficiently replenish NAD+ levels that have declined with age, with the goal of improving brain function, promoting anti-aging, and restoring mitochondrial function.<\/p>\n<p class=\"fw-bold\">Manufactured in Japan<\/p>\n<p class=\"mb-3\">\nTypically, when NAD+ is administered orally (as a supplement) or via IV drip, it breaks down before being taken up by cells, making it extremely difficult to deliver it directly to the brain (due to the blood-brain barrier). Furthermore, since intracellular resynthesis requires an enzyme called NAMPT, which decreases with age, the effectiveness varies from person to person.<\/p>\n<\/div>\n<div class=\"col-12 col-md-5\">\n<img decoding=\"async\" src=\"https:\/\/yamate.clinic\/wp-content\/themes\/yycen\/assets\/img\/external-img\/nad-kit.jpg\" class=\"img-fluid\" lat=\"NAD+\"><\/div>\n<\/div>\n<\/div>\n<div class=\"feature wow fadeInUp\">\n<p class=\"mb-7\">This treatment overcomes these challenges through the following two technical innovations<br class=\"d-none d-sm-block\">As a result, it directly boosts the NAD+ pool in the brain, promising high efficacy.<\/p>\n<div class=\"row justify-content-center\">\n<div class=\"col-sm-6 col-lg-5 mb-5 mb-lg-0\">\n<div class=\"text-center\">\n<div class=\"mb-3\">\n<span class=\"mdi mdi-spray display-5\"><\/span><\/div>\n<h5>Intranasal Administration<\/h5>\n<p class=\"text-start\">By traveling through the olfactory and trigeminal nerve pathways in the nasal mucosa, the drug bypasses the blood-brain barrier and reaches the brain (central nervous system) directly.<\/p>\n<\/div>\n<\/div>\n<div class=\"col-sm-6 col-lg-5 offset-lg-1 mb-5 mb-lg-0\">\n<div class=\"text-center\">\n<div class=\"mb-3\">\n<span class=\"mdi mdi-border-none display-5\"><\/span><\/div>\n<h5>Liposomal Formulation<\/h5>\n<p class=\"text-start\">\nBy encapsulating NAD+ in nanoparticles composed of the same components as cell membranes (lipid bilayers), it is protected from degradation by enzymes in the body and can pass through the cell membrane to reach the interior of the cell (mitochondria) directly.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"service-area content-space-2\">\n<div class=\"container\">\n<div class=\"about wow fadeInUp p-4 border\">\n<div class=\"row justify-content-center justify-content-lg-between\">\n<div class=\"col-11 col-md-5 mb-5 mb-md-0\">\n<div class=\"section-heading mb-7\">\n<h2 class=\"text-primary\">Convenient and Easy-to-Maintain Nasal Sprays<\/h2>\n<\/div>\n<div class=\"col-10\">\n<img decoding=\"async\" src=\"https:\/\/yamate.clinic\/wp-content\/themes\/yycen\/assets\/img\/external-img\/nad-spray.jpg\" class=\"img-fluid\" lat=\"NAD+\"><\/div>\n<\/div>\n<div class=\"col-12 col-md-6\">\n<p class=\"mb-5\">A nasal spray is a method of administering medication by spraying it into the nasal cavity. <br class=\"br\">Because the nasal mucosa has a rich blood supply, certain ingredients can be absorbed without passing through the digestive tract. Additionally, since this method is non-invasive\u2014unlike injections\u2014its use has been expanding across various fields in recent years. Furthermore, a key advantage of intranasal administration is that it is less susceptible to the first-pass effect (metabolism in the liver) compared to oral intake.<\/p>\n<ul class=\"list-checked list-checked-bg-secondary\">\n<li class=\"list-checked-item\">It is easier to maintain than injections or IV drips, making it simple for even busy individuals to incorporate into their daily lives.<\/li>\n<li class=\"list-checked-item\">Since it does not use needles, it is a popular choice for those who dislike injections.<\/li>\n<li class=\"list-checked-item\">Liposome technology encapsulates the active ingredients, ensuring stability and a comfortable user experience.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"service-area content-space-2\">\n<div class=\"container-xl\">\n<div class=\"trouble wow fadeInUp bg-light rounded-3 p-4\">\n<div class=\"row justify-content-between align-items-center\">\n<div class=\"col-12 col-lg-3 text-lg-center\">\n<div class=\"section-heading\">\n<h2 class=\"text-primary\">Recommended for:<\/h2>\n<\/div>\n<\/div>\n<div class=\"col-12 col-lg-8\">\n<ul class=\"list-unstyled\">\n<li><span class=\"mdi mdi-check mdi-24px me-3 text-graybeige\"><\/span>Those who can\u2019t shake off chronic fatigue<\/li>\n<li><span class=\"mdi mdi-check mdi-24px me-3 text-graybeige\"><\/span>hose in their 40s and older who want to strengthen their inner care for health and beauty<\/li>\n<li><span class=\"mdi mdi-check mdi-24px me-3 text-graybeige\"><\/span>Those who want to incorporate daily care into their routine or prefer to do everything at home<\/li>\n<li><span class=\"mdi mdi-check mdi-24px me-3 text-graybeige\"><\/span>Those who want to prevent cognitive decline and other brain function deterioration<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"service-area content-space-2\">\n<div class=\"container\">\n<div class=\"about wow fadeInUp\">\n<div class=\"section-heading mb-3\">\n<h2 class=\"text-primary\">Expected Effects<\/h2>\n<\/div>\n<p class=\"mb-5\">The following effects are expected when this product is sprayed into and absorbed by the nasal cavity.<\/p>\n<div class=\"row justify-content-center\">\n<div class=\"col-lg-10\">\n<ul class=\"list-equal-height list-equal-height-2-cols\">\n<li class=\"list-equal-height-item\">\n<h4>Improved Brain Function<\/h4>\n<p class=\"mb-0\">Improved cognitive function, concentration, and memory.<\/p>\n<\/li>\n<li class=\"list-equal-height-item\">\n<h4>Neuroprotection<\/h4>\n<p class=\"mb-0\">Inhibition of neuroinflammation and improvement of mitochondrial function, leading to the suppression of progression and improvement of symptoms in neurological diseases such as Alzheimer&#8217;s and Parkinson&#8217;s.<\/p>\n<\/li>\n<li class=\"list-equal-height-item\">\n<h4>Improved Physical Functioning<\/h4>\n<p class=\"mb-0\">Reduced fatigue and increased energy levels.<\/p>\n<\/li>\n<li class=\"list-equal-height-item\">\n<h4>Anti-Aging &#038; Metabolic Support<\/h4>\n<p class=\"mb-0\">Delays the aging process, prevents and improves metabolic-related diseases, and improves mood.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"service-area content-space-2\">\n<div class=\"container\">\n<div class=\"method wow fadeInUp\">\n<div class=\"section-heading mb-7\">\n<h2 class=\"text-primary\">Treatment Method (Usage and Dosage)<\/h2>\n<\/div>\n<div class=\"w-lg-75\">\n<p class=\"mb-3\">Please administer the nasal spray yourself, following your doctor\u2019s instructions.<\/p>\n<ul class=\"list-unstyled ms-3\">\n<li class=\"d-flex py-3 border-bottom\"><span class=\"me-4 label\">Indications<\/span>Adults<\/li>\n<li class=\"d-flex py-3 border-bottom\"><span class=\"me-4 label\">Usage<\/span>Spray 1 to 2 pumps into each nostril.<br\nclass=\"br\">Tilt your head back slightly while doing so.<\/li>\n<li class=\"d-flex py-3 border-bottom\"><span\nclass=\"me-4 label\">Dosage<\/span>2\u20133 times daily. Use one bottle within 14 days; store in the refrigerator.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"service-area content-space-2\">\n<div class=\"container\">\n<div class=\"notice wow fadeInUp\">\n<div class=\"section-heading mb-7\">\n<h2 class=\"text-primary\">Precautions<\/h2>\n<\/div>\n<p class=\"mb-5\">Before undergoing this treatment, you must fully understand the following risks.<\/p>\n<ul class=\"list-unstyled item-box\">\n<li>\n<div class=\"d-sm-flex\">\n<span class=\"sub\">This is an investigational treatment:<\/span><span>Intranasal liposomal NAD+ is a groundbreaking treatment based on theoretical and anatomical evidence, but it is currently in the research phase. Large-scale clinical trial data in humans is limited, and long-term safety and definitive efficacy have not been fully established.<\/span><\/div>\n<\/li>\n<li>\n<div class=\"d-sm-flex\">\n<span class=\"sub\">Safety and Ingredients:<\/span><span>The ingredients of the nasal spray (NAD+ itself, preservatives, etc.) and its pH may affect absorption and stability in the nasal mucosa. <\/span><\/div>\n<\/li>\n<li>\n<div class=\"d-sm-flex\">\n<span class=\"sub\">Side Effects:<\/span><span>Transient nasal irritation, dryness, and mild headaches may occur. If you experience severe pain, persistent bleeding, or allergic symptoms (such as a rash or difficulty breathing), stop using the product immediately and contact our clinic.<\/span><\/div>\n<\/li>\n<li>\n<div class=\"d-sm-flex\">\n<span class=\"sub\">Unapproved Drug \/ Self-Pay Treatment:<\/span><span>Since this medication is not approved under Japan\u2019s Pharmaceutical Affairs Law, the full cost of treatment must be borne by the patient (self-pay). Additionally, it is not covered by the adverse reaction relief system.<\/span><\/div>\n<\/li>\n<li>\n<div class=\"d-sm-flex\">\n<span class=\"sub\">Technical Difficulty and Cost:<\/span><span>Liposomal NAD+ is technically very difficult to produce, and due to high manufacturing costs, the drug price is set at a high level. <\/span><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"service-area content-space-t-2 content-space-b-3\">\n<div class=\"container\">\n<div class=\"price wow fadeInUp\">\n<div class=\"section-heading mb-7\">\n<h2 class=\"text-primary\">Price<span class=\"fs-5\">\uff08include tax\uff09<\/span><\/h2>\n<\/div>\n<div class=\"row mb-5 justify-content-center\">\n<div class=\"col-12 col-sm-11\">\n<div class=\"alert bg-light border mb-3\">\n<div class=\"row p-0 align-items-center\">\n<div class=\"col-12 col-md-4\">\n<h6 class=\"mb-0\">Nasal Liposome NAD+ Kit<\/h6>\n<\/div>\n<div class=\"col-12 col-md-4 text-end\">\n<span class=\"me-3\">1 bottle (10\u201314 days)<\/span><span class=\"amount\">\u00a555,000<\/span><\/div>\n<div class=\"col-12 col-md-4 text-end\">\n<span class=\"me-3\">1-month set (3 bottles)<\/span><span class=\"amount\">\u00a5148,500<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<p><\/main><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Future-Oriented Conditioning NAD+ Nasal Liposome Kit A new, needle-free NAD+ routine. Home External Nad Nasal  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1575,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/pages\/1908"}],"collection":[{"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/comments?post=1908"}],"version-history":[{"count":9,"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/pages\/1908\/revisions"}],"predecessor-version":[{"id":2206,"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/pages\/1908\/revisions\/2206"}],"up":[{"embeddable":true,"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/pages\/1575"}],"wp:attachment":[{"href":"https:\/\/www.yamate.clinic\/en\/wp-json\/wp\/v2\/media?parent=1908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}